A fast time-domain algorithm for the assessment of tissue blood flow in laser-Doppler flowmetry

Binzoni, Tiziano and Seelamantula, Chandra Sekhar and Van De Ville, Dimitri (2010) A fast time-domain algorithm for the assessment of tissue blood flow in laser-Doppler flowmetry. In: Physics in Medicine and Biology, 55 (13). N383-N394.

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Abstract

In this study, we derive a fast, novel time-domain algorithm to compute the nth-order moment of the power spectral density of the photoelectric current as measured in laser-Doppler flowmetry (LDF). It is well established that in the LDF literature these moments are closely related to fundamental physiological parameters, i.e. concentration of moving erythrocytes and blood flow. In particular, we take advantage of the link between moments in the Fourier domain and fractional derivatives in the temporal domain. Using Parseval's theorem, we establish an exact analytical equivalence between the time-domain expression and the conventional frequency-domain counterpart. Moreover, we demonstrate the appropriateness of estimating the zeroth-, first- and second-order moments using Monte Carlo simulations. Finally, we briefly discuss the feasibility of implementing the proposed algorithm in hardware.

Item Type:	Journal Article
Publication:	Physics in Medicine and Biology
Publisher:	Institute of Physics
Additional Information:	Copyright of this article belongs to Institute of Physics.
Department/Centre:	Division of Electrical Sciences > Electrical Engineering
Date Deposited:	13 Jul 2010 09:51
Last Modified:	19 Sep 2010 06:11
URI:	http://eprints.iisc.ac.in/id/eprint/29188

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