Raman, TS and Sharma, BVS and Jayaraman, J and Ramasarma, T (1965) Biosynthesis of coenzyme Q in microorganisms. In: Archives of Biochemistry and Biophysics, 110 (1). pp. 75-84.
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Abstract
Incorporation of mevalonate-2-C14, acetate-1-C14, and formate-C14 into the lipids of microorganisms was studied. In the case of four bacteria tested—Agrobacterium tumefaciens, Azotobacter vinelandii, Escherichia coli, and a Pseudomonas species—the various homologues of coenzyme Q present were not labeled with any of the tracers used, although significant amounts of radioactivity were present in the lipids. Both acetate and mevalonate were incorporated into coenzyme Q and sterol of the moulds, Aspergillus niger, Neurospora crassa, Penicillium chrysogenum, and Gibberella fujickuroi, and a yeast, Torulopsis utilis. Mevalonate was incorporated into the side chain but not the ring, whereas acetate was incorporated into both. It appears that the mevalonate pathway for the synthesis of coenzyme Q is operative only in those organisms which also contain other isoprene compounds such as sterol and carotene.
Item Type: | Journal Article |
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Publication: | Archives of Biochemistry and Biophysics |
Publisher: | Elsevier Science |
Additional Information: | Copyright of this article belongs to Elsevier Science. |
Department/Centre: | Division of Biological Sciences > Biochemistry |
Date Deposited: | 19 May 2010 09:38 |
Last Modified: | 19 Sep 2010 06:07 |
URI: | http://eprints.iisc.ac.in/id/eprint/27935 |
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