Identification of genes associated with tumorigenesis of meibomian cell carcinoma by microarray analysis

Kumar, Arun and Dorairaj, Syril Kumar and Prabhakaran, Venkatesh C and Prakash, Ravi D and Chakraborty, Sanjukta (2007) Identification of genes associated with tumorigenesis of meibomian cell carcinoma by microarray analysis. In: Genomics, 90 (5). pp. 559-566.

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Abstract

Meibomian cell carcinoma (MCC) is a malignant tumor of the meibomian glands located in the eyelids. No information exists on the cytogenctic and genetic aspects of MCC. There is no report on the gene expression profile of MCC. Thus there is a need, for both scientific and clinical reasons, to identify genes and pathways that are involved in the development and progression of MCC. We analyzed the gene expression profile of MCC by the microarray technique. Forty-four genes were upregulated and 149 genes were downregulated in MCC. Differential expression data were confirmed for 5 genes by semiquantitative RT-PCR in MCC tumors: GTF2H4, RBM12, UBE2D3, DDX17, and LZTS1. We found dysregulation of two major pathways in MCC: MAPK and JAK/STAT. Clusters of genes on chromosomes 1, 12, and 19 were dysregUlated in MCC. The data presented here will facilitate the identification of specific markers and therapeutic targets for the treatment of MCC patients. (c) 2007 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Publication:	Genomics
Publisher:	Elsevier Science
Additional Information:	Copyright of this article belongs to Elsevier Science.
Keywords:	Expression profile; Meibomian cell carcinoma; MAPK signaling pathway; JAK/STAT pathway; Microarrays
Department/Centre:	Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Date Deposited:	06 May 2010 09:05
Last Modified:	19 Sep 2010 06:01
URI:	http://eprints.iisc.ac.in/id/eprint/27588

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