A norbornyl route to azasugars: a new synthesis of deoxynojirimycin analogues

Mehta, Goverdhan and Mohal, Narinder (2000) A norbornyl route to azasugars: a new synthesis of deoxynojirimycin analogues. In: Tetrahedron Letters, 41 (30). pp. 5741-5745.

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Abstract

A new synthesis of deoxynojirimycin (DNJ) analogues (galacto-and altrose configuration) has been achieved through a functionalized cyclopentene derivative crafted from the norbornyl system, employing double reductive amination as the key step. The new DNJ analogues have been evaluated against various glycosidases and found to be moderate to strong inhibitors.

Item Type:	Journal Article
Publication:	Tetrahedron Letters
Publisher:	Elsevier Science
Additional Information:	Copyright for this article belongs to Elsevier Science.
Keywords:	azasugars;glycosidase inhibitors;osmylation;reductive amination
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	03 Feb 2005
Last Modified:	19 Sep 2010 04:17
URI:	http://eprints.iisc.ac.in/id/eprint/2695

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