Temperature independent mixing rules to correlate the solubilities of antibiotics and anti-inflammatory drugs in SCCO2

Garlapati, Chandrasekhar and Madras, Giridhar (2009) Temperature independent mixing rules to correlate the solubilities of antibiotics and anti-inflammatory drugs in SCCO2. In: Thermochimica Acta, 496 (1-2). pp. 54-58.

PDF 18.pdf - Published Version Restricted to Registered users only Download (350kB) | Request a copy

Abstract

The accurate experimental determination of the solubilities of antibiotics and anti-inflammatory drugs in supercritical fluids (SCFs) and correlations are essential for the development of supercritical technologies for the pharmaceuticals industry. In this work, the solubilities of penicillinG, penicillinV, flurbiprofen, ketoprofen, naproxen, ibuprofen, aspirin and diflunisal in supercritical carbon dioxide (SCCO2) were correlated using Peng-Robinson equation of state (PR EOS) with the modified Kwak and Mansoori mixing rules (mKM) and with Bartle model. The ability of mKM rules was compared against the conventional mixing rules of van der Waals in correlating the solubilities. In the present model, vapor pressure was considered as an adjustable parameter along with binary interactions parameters. In the proposed model, the constants used in the mixing rule, and vapor pressure expression coefficients are temperature independent. The optimization of these constants with experimental data gives binary interaction parameters along with vapor pressure correlations. Sublimation enthalpies were estimated with both the models compared with literature reported experimental values.

Item Type:	Journal Article
Publication:	Thermochimica Acta
Publisher:	Elsevier Science
Additional Information:	Copyright for this article belongs to Elsevier Science.
Keywords:	Antibiotics drugs; Anti-inflammatory drugs; Peng-Robinson equation of state; Kwak-Mansoori mixing rules; Solubilities; Sublimation enthalpies
Department/Centre:	Division of Mechanical Sciences > Chemical Engineering
Date Deposited:	05 Jan 2010 11:32
Last Modified:	19 Sep 2010 05:54
URI:	http://eprints.iisc.ac.in/id/eprint/25325

Actions (login required)

View Item