Varied Immune Response to FVIII: Presence of Proteolytic Antibodies Directed to Factor VIII in Different Human Pathologies

Wootla, Bharath and Desirazu, Narasimha Rao and Friboulet, Alain and Uda, Taizo and Lacroix-Desmazes, Sebastien and Kaveri, Srini V (2009) Varied Immune Response to FVIII: Presence of Proteolytic Antibodies Directed to Factor VIII in Different Human Pathologies. In: Clinical Reviews in Allergy and Immunology, 37 (2). pp. 97-104.

PDF 13.pdf - Published Version Restricted to Registered users only Download (270kB) | Request a copy

Abstract

The versatility of antibodies is demonstrated by the various functions that they mediate such as neutralization, agglutination, fixation of the complement and its activation, and activation of effector cells. In addition to this plethora of functions, antibodies are capable of expressing enzymatic activity. Antibodies with catalytic function are a result of the productive interplay between the highly evolved machinery of the immune system and the chemical framework used to induce them (antigens). Catalytic antibodies are immunoglobulins with an ability to catalyze the reactions involving the antigen for which they are specific. Catalytic immunoglobulins of the IgM and IgG isotypes have been detected in the serum of healthy donors. In addition, catalytic immunoglobulins of the IgA isotype have been detected in the milk of healthy mothers. Conversely, antigen-specific hydrolytic antibodies have been reported in a number of inflammatory, autoimmune, and neoplastic disorders. The pathophysiological occurrence and relevance of catalytic antibodies remains a debated issue. Through the description of the hydrolysis of coagulation factor VIII as model target antigen, we propose that catalytic antibodies directed to the coagulation factor VIII may play a beneficial or a deleterious role depending on the immuno-inflammatory condition under which they occur.

Item Type:	Journal Article
Publication:	Clinical Reviews in Allergy and Immunology
Publisher:	springer
Additional Information:	Copyright of this article belongs to springer.
Keywords:	Factor VIII;Anti-FVIII antibodies;Catalytic antibody
Department/Centre:	Division of Biological Sciences > Biochemistry
Date Deposited:	08 Jan 2010 05:08
Last Modified:	19 Sep 2010 05:47
URI:	http://eprints.iisc.ac.in/id/eprint/23834

Actions (login required)

View Item