Inhibition of the biosynthesis of isoprenoid compounds by phenolic acids in the rat brain

Ranganathan, S and Ramasarma, T (1974) Inhibition of the biosynthesis of isoprenoid compounds by phenolic acids in the rat brain. In: Journal of Neurochemistry, 22 (6). pp. 987-990.

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Abstract

The incorporation of [2-14C]mevalonate into nonsaponifiable lipids by rat brain homogenates is inhibited by phenolic acids derived from tyrosine. The phenyl acids derived from phenylalanine are inhibitory only at very high concentrations compared with phenolic acids. The brain is more sensitive to inhibition by the phenolic acids than the liver. These studies indicate a possible role for phenolic acids in the impairment of cerebral sterol metabolism in phenylketonuria.

Item Type:	Journal Article
Publication:	Journal of Neurochemistry
Publisher:	John Wiley and Sons
Additional Information:	Copyright of this article belongs to John Wiley and Sons.
Department/Centre:	Division of Biological Sciences > Biochemistry
Date Deposited:	19 Dec 2009 07:02
Last Modified:	19 Sep 2010 05:46
URI:	http://eprints.iisc.ac.in/id/eprint/23599

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