Host-specificity of Salmonella enterica serovar Gallinarum: Insights from comparative genomics

Eswarappa, Sandeepa M and Janice, Jessin and Balasundaram, Sudhagar V and Dixit, Narendra M and Chakravortty, Dipshikha (2009) Host-specificity of Salmonella enterica serovar Gallinarum: Insights from comparative genomics. In: Infection Genetics and Evolution, 9 (4). pp. 468-473.

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Abstract

In this study, we have identified the possible genetic factors responsible for fowl-adaptation of Salmonella enterica serovar Gallinarum (S. Gallinarum). By comparing the genes related to Salmonella pathogenicity islands (SPI) of S. Gallinarum with those of Salmonella enterica serovar Enteritidis (S. Enteritidis) we have identified twenty-four positively selected genes. Our results suggest that the genes encoding the structural components of SPI-2 encoded type three secretion apparatus (TTSS) and the effector proteins that are secreted via SPI-1 encoded TTSS have evolved under positive selection pressure in these serovars. We propose that these positively selected genes play important roles in conferring different host-specificities to S. Gallinarum and S. Enteritidis.

Item Type:	Journal Article
Publication:	Infection Genetics and Evolution
Publisher:	Elsevier Science
Additional Information:	Copyright of this article belongs to Elsevier Science.
Keywords:	Salmonella;Positive selection;Host-specificity.
Department/Centre:	Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited:	12 Aug 2009 08:58
Last Modified:	19 Sep 2010 05:37
URI:	http://eprints.iisc.ac.in/id/eprint/21340

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