Tamilselvi, A and Mugeshii, Govindasamy (2009) Inhibition of Peroxidase-Catalyzed Iodination by Cephalosporins: Metallo-beta-Lactamase-Induced Antithyroid Activity of Antibiotics. In: ChemMedChem, 4 (4). pp. 512-516.
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Official URL: http://www3.interscience.wiley.com/journal/1215834...
Abstract
Broad-spectrum antibiotics with heterocyclic side chains strongly inhibit peroxidase-catalyzed iodination in the presence of metallo--lactamase. This suggests that antibiotic resistance due to hydrolysis of the -lactam ring in antibiotics would have negative effects on thyroid activity.
Item Type: | Journal Article |
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Publication: | ChemMedChem |
Publisher: | John Wiley and Sons |
Additional Information: | Copyright of this article belongs to John Wiley and Sons. |
Keywords: | antibiotics;antithyroid drugs;drug resistance;metallo-beta-lactamase;peroxidase. |
Department/Centre: | Division of Chemical Sciences > Inorganic & Physical Chemistry |
Date Deposited: | 25 Aug 2009 10:08 |
Last Modified: | 19 Sep 2010 05:32 |
URI: | http://eprints.iisc.ac.in/id/eprint/20436 |
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