Mechanism of foetal wastage following immunoneutralization of riboflavin carrier protein in the pregnant rat: disturbances in flavin coenzyme levels

Krishnamurthy, Kavita and Surolia, Namita and Adiga, Radhakantha P (1984) Mechanism of foetal wastage following immunoneutralization of riboflavin carrier protein in the pregnant rat: disturbances in flavin coenzyme levels. In: FEBS Letters, 178 (1). pp. 87-91.

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Abstract

Immunoneutralization of maternal RCP results in a >90% decrease in the content and the incorporation of [2-14C]riboflavin into embryonic FAD as well as a percentage redistribution of both embryonic FMN and riboflavin. This is unaccompanied by any discernible changes in flavin distribution pattern in the maternal liver. Embryonic α-glycerophosphate dehydrogenase and NADPH-cytochrome c reductase register significant decreases in activities in the RCP antiserum-treated rats. These alterations readily explain the arrest of foetal growth culminating in pregnancy termination in the antiserum-treated animals.

Item Type:	Journal Article
Publication:	FEBS Letters
Publisher:	Elsevier Science
Additional Information:	Copyright of this article belongs Elsevier science.
Keywords:	Immunoneutralization;RCP;FAD;Fetal wastage;Flavin
Department/Centre:	Division of Biological Sciences > Biochemistry
Date Deposited:	03 Feb 2010 09:42
Last Modified:	01 Mar 2012 07:46
URI:	http://eprints.iisc.ac.in/id/eprint/20091

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