Devireddy, LR and Raghavan, R and Ramachandran, S and Subbarao, SM (1998) Protection of rabbits against lapinized rinderpest virus with purified envelope glycoproteins of peste-des-petits-ruminants and rinderpest viruses. In: Acta virologica, 42 (05). pp. 299-306.
Full text not available from this repository. (Request a copy)Abstract
Haemagglutinin (HA) and fusion (F) proteins of peste-des-petits-ruminants virus (PPRV) and rinderpest virus (RPV) were purified by immunoaffinity chromatography. The purified proteins were characterized by polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate (SDS-PAGE). Rabbit hyperimmune sera were raised against the purified HA and F proteins and assayed by enzyme-linked immunosorbent assay (ELISA), haemagglutination-inhibition (HAI) and virus neutralization (VN) tests. The immunized animals were challenged with a virulent lapinized (rabbit-adapted) strain of RPV: Both HA and F proteins of PPRV protected rabbits against a lethal challenge with lapinized RPV. As expected, RPV HA and F proteins also conferred a similar protection against the homologous challenge. The postchallenge antibody responses were of a true anamnestic type.
| Item Type: | Journal Article |
|---|---|
| Publication: | Acta virologica |
| Publisher: | Slovak Academic Press |
| Additional Information: | Copyright of this article belongs to Slovak Academic Press. |
| Keywords: | peste-des-petits-ruminants;rinderpest;vaccine;viruses; immunity. |
| Department/Centre: | Division of Biological Sciences > Microbiology & Cell Biology |
| Date Deposited: | 27 Nov 2009 05:45 |
| Last Modified: | 27 Nov 2009 05:45 |
| URI: | http://eprints.iisc.ac.in/id/eprint/19537 |
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