Binding of DNA Nucleobases and Nucleosides with Graphene

Varghese, Neenu and Mogera, Umesha and Govindaraj, Achutharao and Das, Anindya and Maiti, Prabal K and Sood, Ajay K and Rao, CNR (2009) Binding of DNA Nucleobases and Nucleosides with Graphene. In: Chemphyschem, 10 (1). pp. 206-210.

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Abstract

Interaction of two different samples of graphene with DNA nucleobases and nucleosides is investigated by isothermal titration calorimetry. The relative interaction energies of the nucleobases decrease in the order guanine (G) > adenine (A) > cytosine (C) > thy mine (T) in aqueous solutions, although the positions of C and T seem to be interchangeable. The same trend is found with the nucleosides. Interaction energies of the A-T and G-C pairs are somewhere between those of the constituent bases. Theoretical calculations including van der Wools interaction and solvation energies give the trend G > A similar to T > C. The magnitudes of the interaction energies of the nucleobases with graphene are similar to those found with single-walled carbon nonotubes.

Item Type:	Journal Article
Publication:	Chemphyschem
Publisher:	Wiley-VCH Verlag GmbH
Additional Information:	Copyright of this article belongs to Wiley-VCH Verlag GmbH.
Keywords:	graphene;isothermal titration calorimetry; nanotubes; nucleobases;nucleosides.
Department/Centre:	Division of Physical & Mathematical Sciences > Physics
Date Deposited:	09 Mar 2009 07:11
Last Modified:	19 Sep 2010 05:27
URI:	http://eprints.iisc.ac.in/id/eprint/19203

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