Regulation of low density lipoprotein receptor mRNA levels by estradiol 17 beta and chorionic gonadotropin in human placenta

Shanker, Y Gopi and Shetty, Usha P and Rao, A Jagannadha (1998) Regulation of low density lipoprotein receptor mRNA levels by estradiol 17 beta and chorionic gonadotropin in human placenta. In: Molecular and Cellular Biochemistry, 187 (1-2). pp. 133-139.

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Abstract

Inhibition of synthesis of estradiol 17 beta by the addition of inhibitors of aromatase, a key enzyme in the biosynthesis of estradiol 17 beta, or addition of tamoxifen - an estrogen receptor antagonist, to human placental minces resulted in an increase in the level of LDL-receptor mRNA. This increase could be blocked by the simultaneous addition of estradiol 17 beta. A concentration dependent effect of estradiol 17 beta on the level of LDL-receptor mRNA was seen both in first trimester, and term placenta. Addition of human chorionic gonadotropin (hCG) to term placental minces also increased the LDL-receptor mRNA levels. When hCG and cycloheximide were added together, an additive effect was observed. The results obtained in this study suggest that the LDL-receptor mRNA levels in the human placenta are regulated by estradiol 17 beta and hCG.

Item Type:	Journal Article
Publication:	Molecular and Cellular Biochemistry
Publisher:	Springer
Additional Information:	Copyright of this article belongs to Springer.
Keywords:	LDL-receptor;estradiol 17 beta;human chorionic gonadotropin; human placenta;progesterone synthesis.
Department/Centre:	Division of Biological Sciences > Molecular Reproduction, Development & Genetics Division of Biological Sciences > Biochemistry
Date Deposited:	31 Dec 2009 07:33
Last Modified:	19 Sep 2010 05:26
URI:	http://eprints.iisc.ac.in/id/eprint/19122

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