Bhandari, Rashna and Mathew, Roy and Vijayachandra, K and Visweswariah, Sandhya S (2000) Tyrosine phosphorylation of the human guanylyl cyclase C receptor. In: Journal Of Biosciences, 25 (4). pp. 339-346.
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Abstract
Tyrosine phosphorylation events are key components of several cellular signal transduction pathways. This study describes a novel method for identification of substrates for tyrosine kinases. Go-expression of the tyrosine kinase EphB1 with the intracellular domain of guanylyl cyclase C (GCG) in Escherichia coli cells resulted in tyrosine phosphorylation of GCC, indicating that GCC is a potential substrate for tyrosine kinases. Indeed, GGC expressed in mammalian cells is tyrosine phosphorylated, suggesting that tyrosine phosphorylation may play a role in regulation of GCC signalling. This is the first demonstration of tyrosine phosphorylation of any member of the family of membrane-associated guanylyl cyclases.
Item Type: | Journal Article |
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Publication: | Journal Of Biosciences |
Publisher: | Indian Academy of Sciences |
Additional Information: | Copyright for this article belongs to Indian Academy of Sciences. |
Keywords: | EphB1;guanylyl cyclase C;tyrosine phosphorylation |
Department/Centre: | Division of Biological Sciences > Molecular Reproduction, Development & Genetics |
Date Deposited: | 03 Sep 2004 |
Last Modified: | 19 Sep 2010 04:16 |
URI: | http://eprints.iisc.ac.in/id/eprint/1905 |
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