Lal, G and Shaila, MS and Nayak, R (2006) Activated mouse T cells downregulate, process and present their surface TCR to cognate anti-idiotypic CD4(+) T cells. In: Immunology And Cell Biology, 84 (2). pp. 145-153.
Full text not available from this repository. (Request a copy)Abstract
The ability of activated T cells to present foreign antigens through the MHC class II pathway has been shown in the case of human, rat and mouse T cells. In the present study, the ability of activated T cells to present their endogenous TCR in association with MHC class II molecules to CD4(+) T cells was shown. Upon activation mouse T cells downregulate their surface TCR, which are degraded into peptides in endosomal/lysosomal compartments. The idiopeptides (peptides derived from the variable region of the TCR) are presented to cognate anti-idiotypic CD4(+) T cells, resulting in activation and proliferation of these cells. Interaction of idiotypic and anti-idiotypic T cells brought about by presentation of TCR idiopeptide may have important implications for T-cell vaccination and perpetuation of T-cell memory not requiring persisting antigen or long-lived memory cells.
| Item Type: | Journal Article |
|---|---|
| Publication: | Immunology And Cell Biology |
| Publisher: | Blackwell Publishing |
| Additional Information: | Copyright of this article belongs to Blackwell Publishong |
| Keywords: | Cell Biology;Immunology;antigen presentation;anti-idiotypic T cell;T-cell memory;T-cell receptor(TCR) |
| Department/Centre: | Division of Biological Sciences > Microbiology & Cell Biology |
| Date Deposited: | 13 Feb 2009 07:38 |
| Last Modified: | 13 Feb 2009 07:38 |
| URI: | http://eprints.iisc.ac.in/id/eprint/18774 |
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