Characterization of the 5 ' flanking region of the Xenopus laevis transforming growth factor-\beta5 (TGF-\beta 5) gene

Vempati, Uma Devi and Kondaiah, Paturu (1998) Characterization of the 5 ' flanking region of the Xenopus laevis transforming growth factor-\beta5 (TGF-\beta 5) gene. In: Gene, 208 (2). pp. 323-329.

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Abstract

Transforming growth factors-beta are potent regulators of cellular proliferation, differentiation and morphogenesis. 2.41 kb of the 5' flanking region of the transforming growth factor-beta 5 (TGF-beta 5) gene has been isolated from a Xenopus laevis genomic library and sequenced. The transcription start site of this gene was determined by 5' RACE method. Promoter activity was demonstrated by transient transfection experiments using luciferase reporter gene constructs in XTC cells. A number of putative recognition sites for transcription factors were found in the 5' flanking region of the TGF-beta 5 gene

Item Type:	Journal Article
Publication:	Gene
Publisher:	Elsevier Science
Additional Information:	Copyright of this article belongs to Elsevier Science.
Keywords:	Promoter;Genomic cloning;Transcription factor sites;Intron.
Department/Centre:	Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Date Deposited:	28 May 2009 09:14
Last Modified:	19 Sep 2010 05:00
URI:	http://eprints.iisc.ac.in/id/eprint/18209

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