Production of paclitaxel by Fusarium solani isolated from Taxus celebica

Chakravarthi, BVSK and Das, Prasanta and Surendranath, Kalpana and Karande, Anjali A and Jayabaskaran, Chelliah (2008) Production of paclitaxel by Fusarium solani isolated from Taxus celebica. In: Journal of Biosciences, 33 (2). pp. 259-267.

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Abstract

A fungus was isolated from the stem cuttings of Taxus celebica, which produced paclitaxel in liquid-grown cultures.The fungus was identified as Fusarium solani based on colony characteristics, morphology of conidia and the 26S rDNA sequence. Paclitaxel was identified by chromatographic and spectroscopic comparison with authentic paclitaxel and its cytotoxic activity towards Jurkat cells in vitro.

Item Type:	Journal Article
Publication:	Journal of Biosciences
Publisher:	Indian Academy of Sciences
Additional Information:	Copyright of this article belongs to Indian Academy of Sciences.
Keywords:	Apoptosis;endophytic fungus;Fusarium solani;paclitaxel.
Department/Centre:	Division of Biological Sciences > Biochemistry Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited:	11 Jul 2008
Last Modified:	19 Sep 2010 04:47
URI:	http://eprints.iisc.ac.in/id/eprint/14932

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