Mathialagan, N and Rao, Jagannadha A (1986) Gonadotropin-releasing hormone in first trimester human placenta: isolation, partial characterization and in vitro biosynthesis. In: Journal of Biosciences, 10 (4). pp. 429-441.
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Using a specific RIA for gonadotropin-releasing hormone (I), the presence of I-like material in the 1st trimester human placenta was demonstrated. The material has been partially characterized using CMC chromatog., high pressure gel permeation chromatog., and reverse-phase C18 HPLC anal. Anal. for bioactivity revealed that placental I is much more active than synthetic I in in vitro rat pituitary LH release assay. In vitro biosynthetic studies using labeled precursors and immunoaffinity chromatog. indicated that 1st trimester human placenta synthesizes I-like material.
| Item Type: | Journal Article |
|---|---|
| Publication: | Journal of Biosciences |
| Publisher: | Indian Academy of Sciences |
| Additional Information: | Copyright of this article belongs to Indian Academy of Sciences. |
| Keywords: | Gonadotropin;trimester human placenta;isolation;partial characterization;in vitro biosynthesis |
| Department/Centre: | Division of Biological Sciences > Biochemistry |
| Date Deposited: | 25 Jun 2008 |
| Last Modified: | 27 Aug 2008 13:29 |
| URI: | http://eprints.iisc.ac.in/id/eprint/14450 |
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