Mehta, Prashant P and Ramasarma, T and Kurup, Ramakrishna CK (1987) Hypocholesterolemic action of 1-ethoxysilatrane. In: Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 920 (1). pp. 102-104.
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Abstract
Intraperitoneal administration of the organosilicon compound 1-ethoxysilatrane to the rat caused a 25% decrease in the concentration of cholesterol in serum without affecting that of triacylglycerols. The specific activity of 3-hydroxy-3-methylglutaryl CoA reductase, the rate-limiting enzyme in cholesterol biosynthesis, was depressed in hepatic microsomes of silatrane-treated animals.
Item Type: | Journal Article |
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Publication: | Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism |
Publisher: | Elsevier |
Additional Information: | Copyright for this article belongs to the Elsevier |
Keywords: | Ethoxysilatrane;Hydroxymethylglutaryl coenzyme A reductase;Hypocholesterolemia;Triacylglycerol;Rat hepatic microsomes |
Department/Centre: | Division of Biological Sciences > Biochemistry |
Date Deposited: | 14 May 2008 |
Last Modified: | 19 Sep 2010 04:44 |
URI: | http://eprints.iisc.ac.in/id/eprint/13978 |
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