Gupta, Veer Bala and Indi, SS and Rao, KSJ (2008) Studies on the role of amino acid stereospecificity in amyloid beta aggregation. In: Journal of Molecular Neuroscience, 34 (1). pp. 35-43.
Full text not available from this repository. (Request a copy)Abstract
Amyloid beta (A \beta) deposition and neurodegeneration are the two related events in the pathogenesis of Alzheimer’s disease. Several factors modulate the conformation and physical properties of A \beta, which in turn affects its biological functions. Among these, age-dependent changes in the stereospecificity of the amino acids comprising A \beta is one such factors. In the present study, we investigated the aggregation property of A \beta as a function of the stereospecificity of amino acids comprising the peptide. We carried out our study by comparing the physical properties of A \beta(1-40) all-L and A \beta(1-40) all-D enantiomers using various biophysical techniques. These results indicated that the aggregation and folding parameters of A \beta are stereospecific and the aggregation property strongly depends upon the amino acid sequence and their stereospecificity. This may possibly help to understand the stereospecific role of amino acids comprising A \beta in its aggregation and its relevance to neurodegeneration.
| Item Type: | Journal Article |
|---|---|
| Publication: | Journal of Molecular Neuroscience |
| Publisher: | Humana Press |
| Additional Information: | Copyright of this article belongs to Springer. |
| Keywords: | Amyloid beta; Enantiomers; Conformation; Aggregation; Stereospecificity; Aging; Fibrils |
| Department/Centre: | Division of Biological Sciences > Microbiology & Cell Biology |
| Date Deposited: | 15 Feb 2008 |
| Last Modified: | 27 Aug 2008 13:11 |
| URI: | http://eprints.iisc.ac.in/id/eprint/13022 |
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