Gullapalli, Sharada and Kurup, Ramakrishna CK and Ramasarma, T (1990) Decavanadate acts like an $\alpha$-adrenergic agonist in redistributing protein kinase C activity. In: FEBS Letters, 267 (1). pp. 93-95.
![]() |
PDF
Decavanadate_acts_like_an_a-adrenergic.pdf Restricted to Registered users only Download (369kB) | Request a copy |
Abstract
Perfusion of rat livers with polyvanadate, but not metavanadate, was found to increase in plasma membrane and decrease in cytosol protein kinase C activity, similar to that obtained with phenylephrine, an $\alpha$-adrenergic agonist. The effect was prevented by phenoxybenzamine, but not by propranolol implicating $\alpha$-adrenergic receptor activation. Comparison of crystal structures of decavanadate and nonadrenaline revealed the occurrence of a structural feature of O-O-O(N) with distances of 5.5 $\AA$ and 2.9 $\AA$.
Item Type: | Journal Article |
---|---|
Publication: | FEBS Letters |
Publisher: | Elsevier Science B.V. |
Additional Information: | Copyright of this article belongs to Elsevier Science B.V. |
Keywords: | Decavanadate;Protein kinase C;α-Adrenergic agonist |
Department/Centre: | Division of Biological Sciences > Biochemistry |
Date Deposited: | 03 Dec 2007 |
Last Modified: | 19 Sep 2010 04:41 |
URI: | http://eprints.iisc.ac.in/id/eprint/12677 |
Actions (login required)
![]() |
View Item |