Idiotypic–Anti-idiotypic B Cell Interactions Generated against a Protective Antigen of a Morbillivirus in Mice

Kaushik, Shibani M and Shaila, MS and Karande, Anjali and Nayak, Rabindranath (2001) Idiotypic–Anti-idiotypic B Cell Interactions Generated against a Protective Antigen of a Morbillivirus in Mice. In: Cellular Immunology, 209 (1). pp. 10-18.

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Abstract

The idiotypic network theory (N. K. Jerne, Ann. Immunol. 125, 373–389, 1974) predicts that any antibody that can be made by an individual would have its preexisting specific complementary B cells in its germline repertoire. We transplanted syngeneic BALB/c mice with live hybridoma cells and demonstrated the simultaneous presence of interacting idiotypic and anti-idiotypic B cells in an individual animal by immuno-cytoadherence assays. Furthermore, we demonstrate that interacting B cells displaying idiotypic and anti-idiotypic antibodies are subjected to lysis by complement. It is therefore tempting to speculate that this complement-sensitive interaction between idiotypic and complementary anti-idiotypic B cells in vivo may provide a mechanism for the regulation of B cell populations.

Item Type:	Journal Article
Publication:	Cellular Immunology
Publisher:	Academic Press
Additional Information:	The copyright of this article belongs to Academic Press
Keywords:	Idiotypic antibody;anti idiotypic antibody;B cell regulation
Department/Centre:	Division of Biological Sciences > Biochemistry Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited:	03 Oct 2007
Last Modified:	19 Sep 2010 04:39
URI:	http://eprints.iisc.ac.in/id/eprint/12030

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