Taurine-conjugation critically determines the therapeutic effectiveness of 24-nor-ursodeoxycholic acid (norUDCA) in the treatment of sclerosing cholangitis in Mdr2 (ABCB4) knockout mice

Halilbasic, E and Fickert, P and Fuchbichler, A and Langner, C and Gumhold, J and Silbert, D and Maitra, U and Zatloukal, K and Denk, H and Trauner, M (2007) Taurine-conjugation critically determines the therapeutic effectiveness of 24-nor-ursodeoxycholic acid (norUDCA) in the treatment of sclerosing cholangitis in Mdr2 (ABCB4) knockout mice. In: Journal of Hepatology, 46 . S51-S51.

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Abstract

Background and Aims: We recently demonstrated that norUDCA reverses sclerosing cholangitis and biliary fibrosis in $Mdr2^{-/-}$ mice (Fickert et al., Gastroenterology 2006) and hypothesized that its therapeutic efficacy may be critically related to its relative resistance against taurine- and glycin-conj ugation resulting in cholehepatic shunting and bicarbonate-rich hypercholeresis (Hofmann et al., Hepatology, 2005). Therefore we aimed to compare the therapeutic mechanisms and effects of norUDCA and its taurine conjugate (TnorUDCA) in the $Mdr2^{-/-}$ model for sclerosing cholangitis.

Item Type:	Journal Article
Publication:	Journal of Hepatology
Publisher:	Elsevier
Additional Information:	Copyright of this article belongs to Elsevier.
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	07 Aug 2007
Last Modified:	04 Jan 2013 10:58
URI:	http://eprints.iisc.ac.in/id/eprint/11661

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