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Basal ganglia contributions during the learning of a visuomotor rotation: Effect of dopamine, deep brain stimulation and reinforcement

Singh, Puneet and Lenka, Abhishek and Stezin, Albert and Jhunjhunwala, Ketan and Pal, Pramod Kumar and Ghosal, Ashitava and Murthy, Aditya (2019) Basal ganglia contributions during the learning of a visuomotor rotation: Effect of dopamine, deep brain stimulation and reinforcement. In: EUROPEAN JOURNAL OF NEUROSCIENCE .

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Official URL: https://dx.doi.org/ 10.1111/ejn.14494

Abstract

It is commonly thought that visuomotor adaptation is mediated by the cerebellum while reinforcement learning is mediated by the basal ganglia. In contrast to this strict dichotomy, we demonstrate a role for the basal ganglia in visuomotor adaptation (error-based motor learning) in patients with Parkinson's disease (PD) by comparing the degree of motor learning in the presence and absence of dopamine medication. We further show similar modulation of learning rates in the presence and absence of subthalamic deep brain stimulation. We also report that reinforcement is an essential component of visuomotor adaptation by demonstrating the lack of motor learning in patients with PD during the ON-dopamine state relative to the OFF-dopamine state in the absence of a reinforcement signal. Taken together, these results raise the possibility that the basal ganglia modulate the gain of visuomotor adaptation based on the reinforcement received at the end of the trial.

Item Type: Journal Article
Additional Information: copyright for this article belongs to WILEY
Department/Centre: Division of Biological Sciences > Centre for Neuroscience
Division of Interdisciplinary Research > Centre for Biosystems Science and Engineering
Division of Mechanical Sciences > Mechanical Engineering
Depositing User: Id for Latest eprints
Date Deposited: 06 Sep 2019 06:52
Last Modified: 06 Sep 2019 06:52
URI: http://eprints.iisc.ac.in/id/eprint/63462

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