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Novel multimeric IL-1 receptor antagonist for the treatment of rheumatoid arthritis

Pasi, Shweta and Kant, Ravi and Gupta, Sarika and Surolia, Avadhesha (2015) Novel multimeric IL-1 receptor antagonist for the treatment of rheumatoid arthritis. In: BIOMATERIALS, 42 . pp. 121-133.

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Official URL: http://dx.doi.org/ 10.1016/j.biomaterials.2014.11....

Abstract

Protein therapeutics targeting inflammatory mediators have shown great promise for the treatment of autoimmunities such as rheumatoid arthritis (RA). However, a significant challenge in this area has been their low in vivo stability and consequently their severely compromised therapeutic efficacy. One such therapeutic molecule IL-1 receptor antagonist (IL-1ra), used in the treatment of rheumatoid arthritis, has displayed only modest efficacy in human clinical trials owing to its short biological half-life. Herein, we report a novel approach to conglomerate individual protein entities into a drug depot by incorporation of an amyloidogenic motif Lys-Phe-Phe-Glu (KFFE) thereby dramatically improving their systemic persistence and in turn their therapeutic efficacy in a mice model of autoimmune arthritis. (C) 2014 Elsevier Ltd. All rights reserved.

Item Type: Journal Article
Keywords: IL-1 receptor antagonist; Multimeric; Rheumatoid arthritis; Anakinra
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Depositing User: Id for Latest eprints
Date Deposited: 19 Mar 2015 12:06
Last Modified: 19 Mar 2015 12:06
URI: http://eprints.iisc.ac.in/id/eprint/51037

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