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Immunogen design for HIV-1 and influenza

Rathore, Ujjwal and Kesavardhana, Sannula and Mallajosyula, Vamsee Aditya V and Varadarajan, Raghavan (2014) Immunogen design for HIV-1 and influenza. In: BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1844 (11, SI). pp. 1891-1906.

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Official URL: http://dx.doi.org/ 10.1016/j.bbapap.2014.05.010

Abstract

Vaccines provide the most cost effective defense against pathogens. Although vaccines have been designed for a number of viral diseases, a vaccine against HIV-1 still remains elusive. In contrast while there are excellent influenza vaccines, these need to be changed every few years because of antigenic drift and shift The recent discovery of a large number of broadly neutralizing antibodies (bNAbs) and structural characterization of the conserved epitopes targeted by them presents an opportunity for structure based HIV-1 and influenza A vaccine design. We discuss strategies to design immunogens either targeting a particular antigenic region or focusing on native structure stabilization. This article is part of a Special Issue entitled: Recent advances in molecular engineering of antibody. (C) 2014 Elsevier B.V. All rights reserved.

Item Type: Journal Article
Additional Information: Copy right for this article belongs to the ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
Keywords: Vaccine; Protein minimization; Native trimer; Stability; Glycosylation
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Depositing User: Id for Latest eprints
Date Deposited: 28 Nov 2014 04:38
Last Modified: 28 Nov 2014 04:38
URI: http://eprints.iisc.ac.in/id/eprint/50325

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