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Current trends in modeling hostpathogen interactions

Mukherjee, Sumanta and Sambarey, Awanti and Prashanthi, Karyala and Chandra, Nagasuma (2013) Current trends in modeling hostpathogen interactions. In: WILEY INTERDISCIPLINARY REVIEWS-DATA MINING AND KNOWLEDGE DISCOVERY, 3 (2). pp. 109-128.

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Official URL: http://dx.doi.org/10.1002/widm.1085

Abstract

The rapid emergence of infectious diseases calls for immediate attention to determine practical solutions for intervention strategies. To this end, it becomes necessary to obtain a holistic view of the complex hostpathogen interactome. Advances in omics and related technology have resulted in massive generation of data for the interacting systems at unprecedented levels of detail. Systems-level studies with the aid of mathematical tools contribute to a deeper understanding of biological systems, where intuitive reasoning alone does not suffice. In this review, we discuss different aspects of hostpathogen interactions (HPIs) and the available data resources and tools used to study them. We discuss in detail models of HPIs at various levels of abstraction, along with their applications and limitations. We also enlist a few case studies, which incorporate different modeling approaches, providing significant insights into disease. (c) 2013 Wiley Periodicals, Inc.

Item Type: Journal Article
Additional Information: Copyright for this article belongs to WILEY PERIODICALS, SAN FRANCISCO, USA
Department/Centre: Division of Biological Sciences > Biochemistry
Division of Biological Sciences > Molecular Biophysics Unit
Division of Physical & Mathematical Sciences > Mathematics
Depositing User: Francis Jayakanth
Date Deposited: 28 Mar 2013 11:53
Last Modified: 28 Mar 2013 11:53
URI: http://eprints.iisc.ac.in/id/eprint/46245

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