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Distribution of simple repetitive (TG/CA)n and (CT/AG)n sequences in human and rodent genomes

Tripathi, J and Brahmachari, SK (1991) Distribution of simple repetitive (TG/CA)n and (CT/AG)n sequences in human and rodent genomes. In: Journal of Biomolecular Structure & Dynamics, 9 (2). pp. 387-397.

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Official URL: http://www.ncbi.nlm.nih.gov/pubmed/1741969


Sixteen million nucleotide sequence of genome of various organisms have been analysed to detect and study the extent of occurrence of simple repetitive sequences. Two sequence motifs (TG/CA)n and (CT/AG)n capable of adopting unusual DNA structures, left handed Z-conformation and triple-helical conformation respectively, are found to be abundant in rodent and human genomes, but almost completely absent in bacterial genome. (TG/CA)n and (CT/AG)n sequences are present mostly in the intron or 5'/3' flanking regions of the genes. The presence of such repeat motifs in genomic sequence of higher eukaryotes has been correlated with their possible functional significance in nucleosome organization, recombination and gene expression.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Adenine Press.
Keywords: Complete Nucleotide-Sequence;Tumor Necrosis Factor;Delta-Heavy-Chain;Factor-I Gene;Z-Dna;Globin Gene;Structural-Analysis;Escherichia-Coli;Evolution;Rat.
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Depositing User: Ms Mary Ranjeetha
Date Deposited: 11 Nov 2010 05:15
Last Modified: 11 Nov 2010 05:15
URI: http://eprints.iisc.ac.in/id/eprint/33740

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