Stereochemically Constrained Linear Peptides. Conformations of Peptides Containing \alpha-Aminoisobutyric Acid

Nagaraj, R and Shamala, N and Balaram, P (1979) Stereochemically Constrained Linear Peptides. Conformations of Peptides Containing \alpha-Aminoisobutyric Acid. In: Journal of the American Chemical Society, 101 (1). pp. 16-20.

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Abstract

1H NMR studies of the protected \alpha-aminoisobutyric acid containing peptides Z-Aib-Pro-Aib-Ala-OMe and Z-Aib-Pro-Aib-OMe suggest that these molecules adopt well-defined conformations in solution. Evidence for type III \beta-bend structures is presented and an incipient $3_{10}$ helical conformation is proposed for the tetrapeptide. The interpretation of the NMR data is further substantiated by the crystal structure of the tetrapeptide. which shows two consecutive type III \beta bends in the solid state.

Item Type:	Journal Article
Publication:	Journal of the American Chemical Society
Publisher:	American Chemical Society
Additional Information:	Copyright for this article belongs to American Chemical Society.
Department/Centre:	Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited:	17 May 2005
Last Modified:	19 Sep 2010 04:18
URI:	http://eprints.iisc.ac.in/id/eprint/3213

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