Gupta, Goutam and Sasisekharan, V (1978) Theoretical calculations of base-base interactions in nucleic acids: II Stacking interactions in polynucleotides. In: Nucleic Acids Research, 5 (5). pp. 1655-1673.
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Base-base interactions were computed for single- and double- stranded polynucleotides, for all possible base sequences. In each case, both right and left stacking arrangements are energetically possible. The preference of one over the other depends upon the base-sequence and the orientation of the bases with respect to helix-axis. Inverted stacking arrangement is also energetically possible for both single- and double-stranded polynucleotides. Finally, interaction energies of a regular duplex and the alternative structures3 were compared. It was found that the type II model3 is energetically more favourable than the rest.
| Item Type: | Journal Article |
|---|---|
| Publication: | Nucleic Acids Research |
| Publisher: | Oxford University Press |
| Additional Information: | Copyright of this article belongs to Oxford University Press. |
| Department/Centre: | Division of Biological Sciences > Molecular Biophysics Unit |
| Date Deposited: | 17 Dec 2009 06:20 |
| Last Modified: | 17 Dec 2009 06:20 |
| URI: | http://eprints.iisc.ac.in/id/eprint/24903 |
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