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Perinbam, Kumar and Balaram, Hemalatha and Row, Tayur N Guru and Gopal, Balasubramanian (2017) Probing the influence of non-covalent contact networks identified by charge density analysis on the oxidoreductase BacC. In: PROTEIN ENGINEERING DESIGN & SELECTION, 30 (3, SI). pp. 265-272.
Pareek, Vidhi and Samanta, Moumita and Joshi, Niranjan V and Balaram, Hemalatha and Murthy, Mathur RN and Balaram, Padmanabhan (2016) Connecting Active-Site Loop Conformations and Catalysis in Triosephosphate Isomerase: Insights from a Rare Variation at Residue96 in the Plasmodial Enzyme. In: CHEMBIOCHEM, 17 (7). pp. 620-629.
Kumar, Sanjeev and Prakash, Sunita and Gupta, Kallol and Dongre, Aparna and Balaram, Padmanabhan and Balaram, Hemalatha (2016) Unexpected functional implication of a stable succinimide in the structural stability of Methanocaldococcus jannaschii glutaminase. In: NATURE COMMUNICATIONS, 7 .
Srinivasan, Bharath and Forouhar, Farhad and Shukla, Arpit and Sampangi, Chethana and Kulkarni, Sonia and Abashidze, Mariam and Seetharaman, Jayaraman and Lew, Scott and Mao, Lei and Acton, Thomas B and Xiao, Rong and Everett, John K and Montelione, Gaetano T and Tong, Liang and Balaram, Hemalatha (2014) Allosteric regulation and substrate activation in cytosolic nucleotidase II from Legionella pneumophila. In: FEBS JOURNAL, 281 (6). pp. 1613-1628.
Williams, Sunanda Margrett and Chandran, Anu V and Vijayabaskar, Mahalingam S and Roy, Sourav and Balaram, Hemalatha and Vishveshwara, Saraswathi and Vijayan, Mamannamana and Chatterji, Dipankar (2014) A Histidine Aspartate Ionic Lock Gates the Iron Passage in Miniferritins from Mycobacterium smegmatis. In: JOURNAL OF BIOLOGICAL CHEMISTRY, 289 (16). pp. 11042-11058.
Banerjee, Sanchari and Agrawal, Monika J and Mishra, Diptimayee and Sharan, Siddharth and Balaram, Hemalatha and Savithri, Handanhal S and Murthy, Mathur RN (2014) Structural and kinetic studies on adenylosuccinate lyase from Mycobacterium smegmatis and Mycobacterium tuberculosis provide new insights on the catalytic residues of the enzyme. In: FEBS JOURNAL, 281 (6). pp. 1642-1658.
Ali, Rustam and Kumar, Sanjeev and Balaram, Hemalatha and Sarma, Siddhartha P (2013) Solution nuclear magnetic resonance structure of the GATase subunit and structural Basis of the interaction between GATase and ATPPase subunits in a two-subunit-type GMPS from methanocaldococcus jannaschii. In: Biochemistry, 52 (25). pp. 4308-4323.
Ali, Rustam and Kumar, Sanjeev and Balaram, Hemalatha and Sarma, Siddhartha P (2012) H-1, C-13, N-15 assignment and secondary structure determination of glutamine amido transferase subunit of gaunosine monophosphate synthetase from Methanocaldococcus jannaschii. In: BIOMOLECULAR NMR ASSIGNMENTS, 6 (2). pp. 193-196.
Samanta, Moumita and Murthy, MRN and Balaram, Hemalatha and Balaram, Padmanabhan (2011) Revisiting the Mechanism of the Triosephosphate Isomerase Reaction: The Role of the Fully Conserved Glutamic Acid 97 Residue. In: ChemBioChem, 12 (12). pp. 1885-1895.
Samanta, Moumita and Banerjee, Mousumi and Murthy, Mathur RN and Balaram, Hemalatha and Balaram, Padmanabhan (2011) Probing the role of the fully conserved Cys126 in triosephosphate isomerase by site-specific mutagenesis - distal effects on dimer stability. In: FEBS Journal, 278 (11). pp. 1932-1943.
Samanta, Moumita and Banerjee, Mousumi and Murthy, Mathur RN and Balaram, Hemalatha and Balaram, Padmanabhan (2011) Probing the role of the fully conserved Cys126 in triosephosphate isomerase by site-specific mutagenesis - distal effects on dimer stability. In: FEBS Journal, 278 (11). pp. 1932-1943.
Banerjee, Mousumi and Balaram, Hemalatha and Joshi, NV and Balaram, P (2011) Engineered dimer interface mutants of triosephosphate isomerase: the role of inter-subunit interactions in enzyme function and stability. In: Protein Engineering Design and Selection, 24 (5). pp. 463-472.
Bulusu, Vinay and Thakur, Suman S and Venkatachala, Roopa and Balaram, Hemalatha (2011) Mechanism of growth inhibition of intraerythrocytic stages of Plasmodium falciparum by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR). In: Molecular and Biochemical Parasitology, 177 (1). pp. 1-11.
Bhat, Javaid Yousuf and Venkatachala, Roopa and Singh, Kavita and Gupta, Kallol and Sarma, Siddhartha P and Balaram, Hemalatha (2011) Ammonia Channeling in Plasmodium falciparum GMP Synthetase: Investigation by NMR Spectroscopy and Biochemical Assays. In: Biochemistry, 50 (16). pp. 3346-3356.
Mehrotra, Sonali and Mylarappa, BN and Iyengar, Prathima and Balaram, Hemalatha (2010) Studies on active site mutants of P-falciparum adenylosuccinate synthetase: Insights into enzyme catalysis and activation. In: Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics, 1804 (10). pp. 1996-2002.
Chakrabarty, Subhra Prakash and Ramapanicker, Ramesh and Mishra, Roli and Chandrasekaran, Srinivasan and Balaram, Hemalatha (2009) Development and characterization of lysine based tripeptide analogues as inhibitors of Sir2 activity. In: Bioorganic & Medicinal Chemistry, 17 (23). pp. 8060-8072.
Banerjee, Mousumi and Balaram, Hemalatha and Balaram, Padmanabhan (2009) Structural effects of a dimer interface mutation on catalytic activity of triosephosphate isomerase.The role of conserved residues and complementary mutations. In: FEBS Journal, 276 (15). pp. 4169-4183.
Gayathri, P and Banerjee, Mousumi and Vijayalakshmi, A and Balaram, Hemalatha and Balaram, P and Murthy, MRN (2009) Biochemical and structural characterization of residue 96 mutants of Plasmodium falciparum triosephosphate isomerase: active-site loop conformation, hydration and identification of a dimer-interface ligand-binding site. In: Acta Crystallographica Section D-Biological Crystallography, 65 (8). pp. 847-857.
Gayathri, P and Subbayya, IN Sujay and Ashok, Chethan S and Selvi, T Senthamizh and Balaram, Hemalatha and Murthy, MRN (2008) Crystal structure of a chimera of human and plasmodium falciparum hypoxanthine guanine phosphoribosyltransferases provides insights into oligomerization. In: Proteins-Structure Function and Bioinformatics, 73 (4). pp. 1010-1020.
Chakrabarty, Subhra Prakash and Saikumari, Yegnisettipalli Krishnaiah and Bopanna, Monnanda P and Balaram, Hemalatha (2008) Biochemical characterization of Plasmodium falciparum Sir2,a $NAD^+$-dependent deacetylase. In: Molecular and Biochemical Parasitology, 158 (2). pp. 139-151.
Gayathri, P and Balaram, Hemalatha and Murthy, MRN (2007) Structural biology of plasmodial proteins. In: Current Opinion in Structural Biology, 17 (6). pp. 744-754.
Sabareesh, V and Ranganayaki, RS and Raghothama, S and Bopanna, MP and Balaram, Hemalatha and Srinivasan, MC and Balaram, Padmanabhan (2007) Identification and characterization of a library of microheterogeneous cyclohexa-depsipeptides from the fungus. In: Journal of Natural Products, 70 (5). pp. 715-729.
Sabareesh, V and Ranganayaki, RS and Raghothama, Srinivasarao and Bopanna, MP and Balaram, Hemalatha and Srinivasan, MC and Balaram, P (2007) Identification and characterization of a library of microheterogeneous cyclohexadepsipeptides from the fungus Isaria. In: Journal of Natural Products, 70 (5). pp. 715-729.
Gayathri, P and Banerjee, Mousumi and Vijayalakshmi, A and Azeez, Shamina and Balaram, Hemalatha and Balaram, P and Murthy, MRN (2007) Structure of triosephosphate isomerase (TIM) from Methanocaldococcus jannaschii. In: Acta Crystallographica Section D-Biological Crystallography, 63 (2). pp. 206-220.
Parthasarathy, Sampathkumar and Eaazhisai, Kandiah and Balaram, Hemalatha and Balaram, Padmanabhan and Murthy, Mathur RN (2003) Structure of Plasmodium falciparum Triose-phosphate Isomerase-2-Phosphoglycerate Complex at 1.1-Å Resolution. In: Journal of Biological Chemistry, 278 (52). pp. 52461-52470.
Pattanaik, Priyaranjan and Jain, Bimba and Ravindra, Gudihal and Gopi, Hosahudya N and Pal, Prajna P and Balaram, Hemalatha and Balaram, Padmanabhan (2003) Stage-specific profiling of Plasmodium falciparum proteases using an internally quenched multispecificity protease substrate. In: Biochemical and Biophysical Research Communications, 309 (4). pp. 974-979.
Pattanaik, Priyaranjan and Ravindra, Gudihal and Sengupta, Chandana and Maithal, Kapil and Balaram, Padmanabhan and Balaram, Hemalatha (2003) Unusual fluorescence of W168 in Plasmodium falciparum triosephosphate isomerase, probed by single-tryptophan mutants. In: European Journal of Biochemistry, 270 (4). pp. 745-756.
Gopi, Hosahudya N and Ravindra, Gudihal and Pal, Prajna P and Pattanaik, Priyaranjan and Balaram, Hemalatha and Balaram, Padmanabhan (2003) Proteolytic stability of beta-peptide bonds probed using quenched fluorescent substrates incorporating a hemoglobin cleavage site. In: FEBS Letters, 535 (1-3). pp. 175-178.
Parthasarathy, S and Balaram, Hemalatha and Balaram, P and Murthy, MRN (2002) Structures of Plasmodium falciparum triosephosphate isomerase complexed to substrate analogues: observation of the catalytic loop in the open conformation in the ligand-bound state. In: Acta Crystallographica Section D: Biological Crystallography, 58 (12). pp. 1992-2000.
Parthasarathy, S and Ravindra, G and Balaram, Hemalatha and Balaram, P and Murthy, MRN (2002) Structure of the Plasmodium falciparum Triosephosphate Isomerase-Phosphoglycolate Complex in Two Crystal Forms: Characterization of Catalytic Loop Open and Closed Conformations in the Ligand-Bound State. In: Biochemistry, 41 (44). 13178 -13188.
Maithal, Kapil and Ravindra, Gudihal and Balaram, Hemalatha and Balaram, Padmanabhan (2002) Inhibition of Plasmodium falciparum Triose-phosphate Isomerase by Chemical Modification of an Interface Cysteine: Electrospray Ionization Mass Spectrometric Analysis of Differential Cysteine Reactivities. In: Journal of Biological Chemistry, 277 (28). pp. 25106-25114.
Maithal, Kapil and Ravindra, Gudihal and Nagaraj, G and Singh, Kumar S and Balaram, Hemalatha and Balaram, P (2002) Subunit interface mutation disrupting an aromatic cluster in Plasmodium falciparum triosephosphate isomerase: effect on dimer stability. In: Protein Engineering, 15 (7). pp. 575-584.
Singh, Kumar S and Maithal, Kapil and Balaram, Hemalatha and Balaram, P (2001) Synthetic peptides as inactivators of multimeric enzymes: inhibition of Plasmodium falciparum triosephosphate isomerase by interface peptides. In: FEBS Letters, 501 (1). pp. 19-23.
Nagaraj, G and Uma, MV and Shivayogi, MS and Balaram, Hemalatha (2001) Antimalarial Activities of Peptide Antibiotics Isolated from Fungi. In: Antimicrobial Agents And Chemotherapy, 45 (1). pp. 145-149.
Ray, Soumya S and Balaram, Hemalatha and Balaram, P (1999) Unusual stability of a multiply nicked form of Plasmodium falciparum triosephosphate isomerase. In: Chemistry and Biology, 6 (9). pp. 625-637.
Gokhale, RS and Ray, Soumya S and Balaram, Hemalatha and Balaram, Padmanabhan (1998) Unfolding of Plasmodium falciparum triosephosphate isomerase in urea and guanidinium chloride solutions. Evidence for a novel disulfide exchange reaction in a covalently crosslinked mutant. In: Biochemistry, 38 (1). pp. 423-431.
Velanker, Sameer S and Ray, Soumya S and Gokhale, Rajesh S and Suma, S and Balaram, Hemalatha and Balaram, P and Murthy, MRN (1997) Triosephosphate isomerase from Plasmodium falciparum: the crystal structure provides insights into antimalarial drug design. In: Structure, 5 (6). pp. 751-761.
Karle, Isabella L and Flippen-Anderson, Judith L and Uma, K and Balaram, Hemalatha and Balaram, P (1990) Peptide Design: Influence of a Guest Aib-Pro Segment on the Stereochemistry of an Oligo-Val Sequence-Solution Conformations and Crystal Structure of Boc-(Val)2-Aib-Pro-(Val)3-OMe. In: Biopolymers, 29 (10-11). pp. 1433-1442.
Moretto, V and Crisma, M and Bonora, GM and Toniolo, C and Balaram, Hemalatha and Balaram, P (1989) Comparison of the Effect of Five Guest Residues on the \beta-Sheet Conformation of Host ${(L-Val)}_n$ Oligopeptides. In: Macromolecules, 22 (7). pp. 2939-2944.
Karle, Isabella L and Flippen-Anderson, Judith L and Uma, Kuchibhotla and Balaram, Hemalatha and Balaram, Padmanabhan (1989) \alpha -Helix and Mixed $3_{10}$/ \alpha -helix in Cocrystallized Conformers of Boc-Aib-Val-Aib-Aib-Val-Val-Val-Aib-Val-Aib-Ome. In: Proceedings of the National Academy of Sciences of the United States of America, 86 (3). pp. 765-769.
Uma, K and Balaram, Hemalatha and Raghothama, S and Balaram, Padmanabhan (1988) Simultaneous observation of positive and negative nuclear Overhauser effects in oligopeptides due to segmental motio. In: Biochemical and Biophysical Research Communications, 151 (1). pp. 153-157.
Balaram, Hemalatha and Sukumar, M and Balaram, P (1986) Stereochemistry of \alpha-Aminoisobutyric Acid Peptides in Solution: Conformations of Decapeptides with a Central Triplet of Contiguous L-Amino Acids. In: Biopolymers, 25 (11). pp. 2209-2223.
Balaram, Hemalatha and Prasad, Venkataram BV and Balaram, P (1983) Multiple Conformational States of a Pro-Pro Peptide. Solid-State and Solution Conformations of Boc-Aib-Pro-Pro-NHMe. In: Journal of the American Chemical Society, 105 (12). pp. 4065-4071.
Rao, Narasinga BN and Kumar, Anil and Balaram, Hemalatha and Ravi, A and Balaram, P (1983) Nuclear Overhauser Effects and circular Dichroism as Probes of \beta.-turn Conformations in Acyclic and Cyclic Peptides with Pro-X Sequences. In: Journal of the American Chemical Society, 105 (25). pp. 7423-7428.
Prasad, Venkataram BV and Balaram, Hemalatha and Balaram, P (1982) Type II \beta-Turn Conformation of Pivaloyl-L-Prolyl-\alpha-Aminoisobutyryl-N-Methylamide: Theoretical, Spectroscopic, and X-Ray Studies. In: Biopolymers, 21 (7). pp. 1261-1273.
Balaram, Hemalatha and Prasad, B V Venkataram and Balaram, Padmanabhan (1982) Conformational transitions in a Pro-Pro peptide on dissolution of single crystals. In: Biochemical and Biophysical Research Communications, 109 (3). pp. 825-831.
Prasad, BV Venkataram and Balaram, Hemalatha and Balaram, P (1982) Type II beta-turn conformation of pivaloyl-L-prolyl-a-aminoiso-butyryl-N-methylamide: Theoretical, spectroscopic and X-ray studies. In: Biopolymers, 21 (7). pp. 1261-1273.
Prasad, BV Venkataram and Balaram, Hemalatha and Balaram, P (1982) Type II beta-turn conformation of pivaloyl-L-prolyl-alpha-aminoisobutyryl-N-methylamide: Theoretical, spectroscopic, and X-ray studies. In: Biopolymers, 27 (7). pp. 1261-1273.
Karnawat, Vishakha and Gogia, Spriha and Balaram, Hemalatha and Puranik, Mrinalini (2015) Deciphering Differential Distortion of Purine Substrates by Human and Plasmodium falciparum HGPRT. In: FASEB JOURNAL, 29 (1).
Bandyopadhyay, Debarati and Murthy, Mathur R N and Balaram, Hemalatha and Balaram, Padmanabhan (2015) Probing the role of highly conserved residues in triosephosphate isomerase-analysis of site specific mutants at positions 64 and 75 in the Plasmodial enzyme. In: FEBS JOURNAL, 282 (20). pp. 3863-3882.
