LMCT transition-based red-light photochemotherapy using a tumour-selective ferrocenyl iron(iii) coumarin conjugate

Sarkar, T and Bhattacharyya, A and Banerjee, S and Hussain, A (2020) LMCT transition-based red-light photochemotherapy using a tumour-selective ferrocenyl iron(iii) coumarin conjugate. In: Chemical Communications, 56 (57). pp. 7981-7984.

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Abstract

A rationally designed iron(iii) complex (2a) with pendant ferrocene and naturally occurring coumarin (esculetin) shows LMCT transition-based mitochondria-targeted red-light (600-720 nm) induced apoptotic toxicity against cancer cells but remains innocuous in the dark and to normal cells. © 2020 The Royal Society of Chemistry.

Item Type:	Journal Article
Publication:	Chemical Communications
Publisher:	Royal Society of Chemistry
Additional Information:	The copyright for this article belongs to Royal Society of Chemistry.
Keywords:	Chemotherapy; Organometallics, Apoptotic; Cancer cells; Esculetin; Ferrocenes; Ferrocenyl; Naturally occurring; Photochemotherapy; Red light, Iron compounds, coumarin derivative; ferrocene derivative; iron derivative; antineoplastic agent; coordination compound; coumarin; coumarin derivative; ferric ion; ferrocene; ferrous ion; ligand; metallocene; photosensitizing agent, antineoplastic activity; apoptosis; Article; cancer cell; controlled study; cytotoxicity; drug design; drug structure; drug synthesis; human; human cell; mitochondrion; photochemotherapy; red light; cell proliferation; chemical structure; chemistry; drug effect; drug screening; fluorescence imaging; HeLa cell line; light; synthesis, Antineoplastic Agents; Apoptosis; Cell Proliferation; Coordination Complexes; Coumarins; Drug Screening Assays, Antitumor; Ferric Compounds; Ferrous Compounds; HeLa Cells; Humans; Ligands; Light; Metallocenes; Molecular Structure; Optical Imaging; Photochemotherapy; Photosensitizing Agents
Department/Centre:	Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited:	03 Feb 2023 04:57
Last Modified:	03 Feb 2023 04:57
URI:	https://eprints.iisc.ac.in/id/eprint/79820

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