Enantiospecific total synthesis of 6-epi-(−)-hamigeran B. Intramolecular Heck reaction in a sterically constrained environment

Mehta, Goverdhan and Shinde, Harish M (2003) Enantiospecific total synthesis of 6-epi-(−)-hamigeran B. Intramolecular Heck reaction in a sterically constrained environment. In: Tetrahedron Letters, 44 (37). pp. 7049-7053.

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Abstract

An enantiospecific approach, emanating from the abundantly available chiron R-(+)-limonene, to the biologically potent, novel marine natural products, the hamigerans has been developed in which an intramolecular Heck coupling between aryl triflates and an alkene serves as the pivotal step. Following this strategy, a synthesis of (−)-6-epi-hamigeran B has been accomplished.

Item Type:	Journal Article
Publication:	Tetrahedron Letters
Publisher:	Elsevier Science
Additional Information:	Copyright for this article belongs to Elsevier Science.
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	12 Jul 2004
Last Modified:	19 Sep 2010 04:13
URI:	http://eprints.iisc.ac.in/id/eprint/997

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