Enantiospecific synthesis of (-)-muricatacin from L-(+)- tartaric acid

Prasad, Kavirayani R and Anbarasan, Pazhamalai (2006) Enantiospecific synthesis of (-)-muricatacin from L-(+)- tartaric acid. In: Tetrahedron: Asymmetry, 17 (17). pp. 2465-2467.

PDF Enantiospecific_synthesis_of_muricatacin_from_tartaric_acid.pdf Restricted to Registered users only Download (113kB) | Request a copy

Abstract

Enantiospecific synthesis of (-)-muricatacin, a bio-active lactone comprising of a 5-hydroxyalkylbutan-4-olide structural component has been achieved from L-(+)-tartaric acid. The key step involves a disteroselective reduction of a $C_2$-symmetric 1,4-diketone derived from tartaric acid followed by a selective Grignard reagent addition.

Item Type:	Journal Article
Publication:	Tetrahedron: Asymmetry
Publisher:	Elsevier
Additional Information:	Copyright of this article belongs to Elsevier.
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	30 Nov 2007
Last Modified:	19 Sep 2010 04:33
URI:	http://eprints.iisc.ac.in/id/eprint/9116

Actions (login required)

View Item