Horseradish peroxidase inhibition and antioxidant activity of ebselen and related organoselenium compounds

Mishra, Beena and Priyadarsini, KI and Mohan, Hari and Mugesh, G (2006) Horseradish peroxidase inhibition and antioxidant activity of ebselen and related organoselenium compounds. In: Bioorganic and Medicinal Chemistry Letters, 16 (20). pp. 5334-5338.

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Abstract

Horseradish peroxidase (HRP) inhibition and glutathione peroxidase (GPx) activities of ebselen and some related derivatives are described. These studies show that ebselen and ebselen ditelluride $(EbTe_2)$ with significant antioxidant activity, inhibit the HRP-catalyzed oxidation reactions. In addition, inhibition of lipid peroxidation and singlet oxygen quenching studies were carried out. Although the inhibition of HRP by ebselen is comparable with that of $EbTe_2$, the inhibitory effect on c-radiation induced lipid peroxidation and the GPx activity of ebselen is found to be much higher than that of $EbTe_2$.

Item Type:	Journal Article
Publication:	Bioorganic and Medicinal Chemistry Letters
Publisher:	Elsevier
Additional Information:	Copyright of this article belongs to Elsevier.
Keywords:	Ebselen;Antioxidant;Selenium;Horseradish peroxidase;Lipid peroxidation
Department/Centre:	Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited:	19 Nov 2007
Last Modified:	19 Sep 2010 04:32
URI:	http://eprints.iisc.ac.in/id/eprint/8940

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