A New Hetero-Bimetallic Fe(III)-Mn(I) Complex as a Dual Modality, Theranostic Tool for Photoactivated Anticancer Therapy

Panwar, A and Upadhyay, A and Mukherjee, M and Chanu, P and Roy, M (2024) A New Hetero-Bimetallic Fe(III)-Mn(I) Complex as a Dual Modality, Theranostic Tool for Photoactivated Anticancer Therapy. In: Applied Organometallic Chemistry .

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Abstract

We developed a novel hetero-bimetallic Fe(III)-Mn(I) complex by combining hydroxyl radicals generating Fe(III)-Phenolato/Carboxylato and CO-releasing Mn(I)(CO)3 complexes to achieve a dual-modality theranostic tool for photoactivated anticancer therapy. Fe(III)-Phenolato/Carboxylato and Mn(I)(CO)3 complexes were conjugated through the amide coupling to synthesize the bimetallic Fe(III)-Mn(I) complex (Fe-Mn) and characterized analytically and spectroscopically. Various photophysical assays have confirmed the production of hydroxyl radicals and the release of CO when the biologically benign Fe-Mn complex is activated by visible light (400�700 nm), resulting in a significant increase in luminescence intensity. The cytotoxic potential of the complex, Fe-Mn resulted from the photoactivated enrichment of ROS and CO in the A549 cells with the photoindex of ~35 leaving HPL1D cells unaffected. We probed the caspase 3/7-dependent apoptosis and the theranostic potential of the complex, Fe-Mn on photoactivation in vitro. The hetero-bimetallic Fe(III)-Mn(I) complex (Fe-Mn) provides an ideal example of a dual-modality next-generation theranostic tool for photoactivated anticancer therapy. © 2024 John Wiley & Sons Ltd.

Item Type:	Journal Article
Publication:	Applied Organometallic Chemistry
Publisher:	John Wiley and Sons Ltd
Additional Information:	The copyright for this article belongs to John Wiley and Sons Ltd
Keywords:	Carboxylation; Cytotoxicity; Manganese compounds, Bimetallics; CO induced apoptosis; Enhanced photocytotoxicity; Hetero-bimetallic phototherapeutic agent; Induced apoptosis; Photo-activated; Photoactivated CO release; Photoactivated ROS generation; Photocytotoxicity; Phototherapeutic agent, Cell death
Department/Centre:	Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited:	27 Nov 2024 11:40
Last Modified:	27 Nov 2024 11:40
URI:	http://eprints.iisc.ac.in/id/eprint/86959

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