Synthesis and properties of tailored β-tricalcium phosphate for bone filler applications

Saxena, A and Vignesh, R and Roy, S and Sahai, S and Bhattacharjee, D and Basu, B and Mukherjee, S (2024) Synthesis and properties of tailored β-tricalcium phosphate for bone filler applications. In: International Journal of Applied Ceramic Technology .

PDF Int_Jou_App_Cer_Tec_2024.pdf - Published Version Restricted to Registered users only Available under License Creative Commons GNU LGPL (Software). Download (10MB) | Request a copy

Abstract

The present work reports the synthesis of highly phase pure (> 95) β-TCP and its subsequent conversion into granules for bone graft applications, using an industrial scale proprietary manufacturing route. Following the wet chemical approach, several process parameters, were adjusted for large volume synthesis, including pH, precursor concentration, and ripening time. The granulation process is tailored to facilitate the scalibility and control over morphology, porosity, and pore size. X-ray diffraction analysis confirms the presence of pure β-TCP phase where as Ca/P molar ratio of 1.497 was determined using ICP-OES. Fourier transform infrared spectroscopy depicts the presence of PO43� as a major molecular group. Scanning electron microscopy (SEM) images of the β-TCP powders reveal necking features, a characteristic morphology of β-TCP. SEM images of the β-TCP granules reveal microporosity, which aids in triggering a biological response. The TGA-DTA curve suggests that the weight loss in pure β-TCP is twice as compared with β-TCP containing hydroxyapatite. Furthermore, these β-TCP granules were clinically tested in a few orthopedic and spine surgeries. In all the treated patients, β-TCP granules did not induce any pus formation or infection at the surgical sites, thereby establishing clinically relevant biocompatibility properties. © 2024 The American Ceramic Society.

Item Type:	Journal Article
Publication:	International Journal of Applied Ceramic Technology
Publisher:	John Wiley and Sons Inc
Additional Information:	The copyright for this article belongs to the Publisher.
Keywords:	Grafting (chemical); Grafts; Granulation; X ray powder diffraction, Bone graft; Bone granule; Bone-fillers; Calcium deficient hydroxyapatite; Property; Scanning electron microscopy image; Tri-calcium phosphates; β-TCP; �-TCP granule, Fourier transform infrared spectroscopy
Department/Centre:	Division of Chemical Sciences > Materials Research Centre
Date Deposited:	19 Nov 2024 19:40
Last Modified:	19 Nov 2024 19:40
URI:	http://eprints.iisc.ac.in/id/eprint/86785

Actions (login required)

View Item