Sharma, V and Gowtham, NH and Kundu, B and Balla, VK and Sundaresh, DC and Basu, B (2024) Unraveling Translational Research on Ultra-High Molecular Weight Polyethylene in Total Hip Joint Arthroplasty A Lab-to-Industry-Scale Pilot Study. [Book Chapter]
Full text not available from this repository. (Request a copy)Abstract
Ultra-high molecular weight polyethylene (UHMWPE) has been clinically used over last six decades in the field of orthopedics, especially as acetabular liner (AL) in total hip joint replacement (THR) and tibial inserts for total knee joint replacement (TKR) devices. All these UHMWPE implants were manufactured via conventional machining route. In this chapter, we comprehensively unravel the translational route for developing a new-generation UHMWPE-based AL via injection molding. This chapter focuses not only on the manufacturability of UHMWPE-materials but also on the spectrum of relevant material-properties required for lab-scale-to-prototype development and evaluation. Significant emphasis had been placed on discussing the computational biomechanics results for the modified implant design to validate biomechanical response of the AL in periprosthetic bone. Overall, this chapter provides in-depth knowledge base relevant for manufacturing UHMWPE biomaterial implants, especially for THR. © 2025 selection and editorial matter, Ashok Kumar, Sneha Singh, and Prerna Singh; individual chapters, the contributors.
| Item Type: | Book Chapter |
|---|---|
| Publication: | Emerging Materials and Technologies for Bone Repair and Regeneration |
| Publisher: | CRC Press |
| Additional Information: | The copyright for this article belongs to publisher. |
| Department/Centre: | Division of Chemical Sciences > Materials Research Centre |
| Date Deposited: | 24 Oct 2024 08:48 |
| Last Modified: | 24 Oct 2024 08:48 |
| URI: | http://eprints.iisc.ac.in/id/eprint/86402 |
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