Biswas, A and Maitra, U (2024) Paper-based sensing of pancreatic-cancer biomarker α-chymotrypsin through turn-on lanthanide-luminescence. In: Sensors and Diagnostics .
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Abstract
We report the facile detection of a pancreatic cancer biomarker α-chymotrypsin (Chy) by turn-on, time-gated lanthanide luminescence for the first time. To the best of our knowledge, the non-peptide probe we designed is the simplest one currently available. The probe undergoes Chy-induced release of the sensitizing antenna (2,3-dihydroxynaphthalene), leading to enhanced lanthanide luminescence. The detection protocol was further modified to develop a paper-based sensor and was used to detect Chy in commercial tablets, and to rapidly screen Chy-inhibitors. © 2024 RSC.
| Item Type: | Journal Article |
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| Publication: | Sensors and Diagnostics |
| Publisher: | Royal Society of Chemistry |
| Additional Information: | The copyright for this article belongs to the Authors |
| Department/Centre: | Division of Chemical Sciences > Organic Chemistry |
| Date Deposited: | 27 Aug 2024 09:06 |
| Last Modified: | 27 Aug 2024 09:06 |
| URI: | http://eprints.iisc.ac.in/id/eprint/86057 |
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