Kushwaha, R and Upadhyay, A and Saha, S and Yadav, AK and Bera, A and Dutta, A and Banerjee, S (2024) Cancer phototherapy by CO releasing terpyridine-based Re(i) tricarbonyl complexes via ROS generation and NADH oxidation. In: Dalton Transactions, 53 (32). pp. 13591-13601.
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Abstract
Here, we have synthesized and characterized three visible light responsive terpyridine based-Re(i)-tricarbonyl complexes; Re(CO)3(ph-tpy)Cl (Retp1), Re(CO)3(an-tpy)Cl (Retp2), and Re(CO)3(py-tpy)Cl (Retp3) where ph-tpy = 4�-phenyl-2,2�:6�,2�-terpyridine; an-tpy = 4�-anthracenyl-2,2�:6�,2�-terpyridine, py-tpy = 4�-pyrenyl-2,2�:6�,2�-terpyridine. The structures of Retp1 and Retp2 were confirmed from the SC-XRD data, indicating distorted octahedral structures. Unlike traditional PDT agents, these complexes generated reactive oxygen species (ROS) via type I and type II pathways and oxidized redox crucial NADH (reduced nicotinamide adenine dinucleotide) upon visible light exposure. Retp3 showed significant mitochondrial localization and demonstrated photoactivated anticancer activity (IC50 � 2 µM) by inducing ROS-mediated cell death in cancer cells selectively (photocytotoxicity Index, PI > 28) upon compromising mitochondrial function in A549 cells. Their diagnostic capabilities were ultimately assessed using clinically relevant 3D multicellular tumor spheroids (MCTs). © 2024 The Royal Society of Chemistry.
Item Type: | Journal Article |
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Publication: | Dalton Transactions |
Publisher: | Royal Society of Chemistry |
Additional Information: | The copyright for this article belongs to the Publisher. |
Keywords: | Cancer cells; Diagnosis; Diseases; Mitochondria; Rhenium compounds; Synthesis (chemical), NADH oxidation; Octahedral structures; PDT agents; Phototherapy; Reactive oxygen species; Synthesised; Terpyridines; Tricarbonyl complexes; Visible-light-responsive; XRD, Cell death |
Department/Centre: | Division of Chemical Sciences > Inorganic & Physical Chemistry |
Date Deposited: | 30 Aug 2024 09:24 |
Last Modified: | 30 Aug 2024 09:24 |
URI: | http://eprints.iisc.ac.in/id/eprint/86053 |
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