Network motifs in cellular neurophysiology

Mittal, D and Narayanan, R (2024) Network motifs in cellular neurophysiology. In: Trends in Neurosciences, 47 (7). pp. 506-521.

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Abstract

Concepts from network science and graph theory, including the framework of network motifs, have been frequently applied in studying neuronal networks and other biological complex systems. Network-based approaches can also be used to study the functions of individual neurons, where cellular elements such as ion channels and membrane voltage are conceptualized as nodes within a network, and their interactions are denoted by edges. Network motifs in this context provide functional building blocks that help to illuminate the principles of cellular neurophysiology. In this review we build a case that network motifs operating within neurons provide tools for defining the functional architecture of single-neuron physiology and neuronal adaptations. We highlight the presence of such computational motifs in the cellular mechanisms underlying action potential generation, neuronal oscillations, dendritic integration, and neuronal plasticity. Future work applying the network motifs perspective may help to decipher the functional complexities of neurons and their adaptation during health and disease. © 2024 Elsevier Ltd

Item Type:	Editorials/Short Communications
Publication:	Trends in Neurosciences
Publisher:	Elsevier Ltd
Additional Information:	The copyright for this article belongs to Elsevier Ltd.
Department/Centre:	Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited:	12 Aug 2024 06:07
Last Modified:	12 Aug 2024 06:07
URI:	http://eprints.iisc.ac.in/id/eprint/85266

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