Dysregulated Cerebrospinal Fluid Proteome of Spinocerebellar Ataxia Type 2 and its Clinical Implications

Stezin, A and Sathe, GJ and Gajbhiye, A and Bharadwaj, S and Ghose, V and Bellad, A and Malo, PK and Holla, V and Hegde, S and Bharath, RD and Saini, J and Jain, S and Yadav, R and Pandey, A and Pal, PK (2024) Dysregulated Cerebrospinal Fluid Proteome of Spinocerebellar Ataxia Type 2 and its Clinical Implications. In: Movement Disorders, 39 (8). 1418 - 1423.

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Abstract

Background: Abnormalities in ataxin-2 associated with spinocerebellar ataxia type 2 (SCA2) may lead to widespread disruptions in the proteome. This study was performed to identify dysregulated proteome in SCA2 and to explore its clinical-radiological correlations. Methods: Cerebrospinal fluid (CSF) samples from 21 genetically confirmed SCA2 were subjected to shotgun proteome analysis using mass spectrometry (MS) and tandem mass tag (TMT)-based multiplexing. Proteins with at least 1.5-fold change in abundance were identified. Their relative abundance was measured using parallel reaction monitoring (PRM) and correlated against disease-related factors. Results: Eleven proteins were significantly upregulated in SCA2. They belonged to the family of cell adhesion molecules and granins. Their fold changes showed significant clinical, genetic, and radiological correlations. Conclusions: Significant dysregulation of CSF proteome is seen in SCA2. The dysregulated protein may have potential use in clinical evaluation of patients with SCA2. © 2024 International Parkinson and Movement Disorder Society. © 2024 International Parkinson and Movement Disorder Society.

Item Type:	Journal Article
Publication:	Movement Disorders
Publisher:	John Wiley and Sons Inc
Additional Information:	The copyright for this article belongs to John Wiley and Sons Inc.
Department/Centre:	Autonomous Societies / Centres > Centre for Brain Research
Date Deposited:	24 Sep 2024 11:28
Last Modified:	24 Sep 2024 11:28
URI:	http://eprints.iisc.ac.in/id/eprint/85216

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