Transcranial direct current stimulation-efficacy in mild cognitive impairment: A meta-analysis

Sandhya, G and Malo, PK and Issac, TG (2024) Transcranial direct current stimulation-efficacy in mild cognitive impairment: A meta-analysis. In: Journal of Neurosciences in Rural Practice, 15 (2). pp. 194-202.

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Abstract

Objectives: Mild cognitive impairment (MCI) is a transition state in which individuals have cognitive abilities that are in between those of normal aging and dementia. Although not everyone with MCI develops dementia, the risk of progression to dementia is higher in people with MCI. Interventions at this stage can prevent or delay the onset of dementia. In recent years, studies on non-invasive brain stimulation techniques, namely transcranial direct current stimulation (tDCS), have gained momentum for cognitive enhancement in MCI. Since there are very few studies that also report varied results, it becomes important to analyze the effect of tDCS in MCI. The aim of this study was to systematically review the available evidence about using tDCS for MCI and to assess its efficacy using meta-analysis. Materials and Methods: Eight single-or double-blinded randomized controlled trials were included in the study. Montreal cognitive assessment (MoCA) and mini-mental state examination (MMSE) for global cognition; and digit span test forward and backward, trail-making test (TMT) A and B; and logical memory test (LMT) assessing specific cognitive domains were considered. A random-effects model was used wherein the standardized mean difference (SMD) and its 95 confidence intervals were reported. Results: The effect of the active tDCS (MoCA SMD 0.37, 95% CI �0.22�0.95, MMSE SMD 0.26, 95% CI 0.25�0.77, TMT-A SMD �0.01, 95% CI �0.42�0.40, and LMT SMD 0.80, 95% CI �0.24�1.83) when compared with the sham tDCS was statistically insignificant. Conclusion: The current meta-analysis identified insignificant improvement in cognitive performance with active tDCS treatment as compared to sham tDCS among people with MCI. © 2024 Published by Scientific Scholar on behalf of Journal of Neurosciences in Rural Practice.

Item Type:	Journal Article
Publication:	Journal of Neurosciences in Rural Practice
Publisher:	Scientific Scholar LLC
Additional Information:	The copyright for this article belongs to Scientific Scholar LLC
Department/Centre:	Autonomous Societies / Centres > Centre for Brain Research
Date Deposited:	29 Jul 2024 05:10
Last Modified:	29 Jul 2024 05:10
URI:	http://eprints.iisc.ac.in/id/eprint/85196

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