Sub-acute Sytemic Toxicity Evaluation of Phase Pure Hydroxyapatite in Mus musculus

Hadagalli, K and Bhaskar, N (2024) Sub-acute Sytemic Toxicity Evaluation of Phase Pure Hydroxyapatite in Mus musculus. In: Trends in Biomaterials and Artificial Organs, 38 (1). pp. 29-39.

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Abstract

To prevent a toxic or harmful effect, the biocompatibility of wear debris particles produced by implants and their coatings is particularly crucial. As a follow-up to our previously published work on pilot-scale HA synthesis, the current research looked at the toxicological features of phase pure HA in a mouse animal model. Preclinical biological effects of intraperitoneally administered particles of HA up to a concentration of 100 mg/kg in swiss albino mice were studied over a 28-day period, according to ISO 10993-part 11 and part 12 guidelines. Particle impacts on serum biochemistry levels and full hemogram were investigated. Histopathological examinations were performed on spleen, heart, lung, kidney, and liver tissues. The current study found that all of the experimental mice, both male and female, lived well with a gradual increase in body weight and no notable changes in complete hemogram or blood biochemistry. The lack of any tissue-level toxicity signal by injected HA particles was verified by thorough histological investigation. When compared to commercial HA powders, these good results show the non-toxic nature of phase pure HA powders. This novel class of HA powders may be beneficial in terms of extended usage for joint arthroplasties, enhancing patient compliance and reducing implant failure. © (2024) Society for Biomaterials & Artificial Organs #20004824.

Item Type:	Journal Article
Publication:	Trends in Biomaterials and Artificial Organs
Publisher:	Society for Biomaterials and Artificial Organs - India
Additional Information:	The copyright for this article belongs to Society for Biomaterials and Artificial Organs - India.
Keywords:	Biochemistry; Biocompatibility; Hydroxyapatite; Mammals; Powders; Tissue; Toxicity, 'current; HA powders; Haematology; Harmful effects; Hydroxyapatite nanoparticles; In-vivo; Mus musculus; Phase pure; Phase pure hydroxyapatites; Toxic effect, Histology
Department/Centre:	Division of Chemical Sciences > Materials Research Centre
Date Deposited:	27 Aug 2024 11:43
Last Modified:	27 Aug 2024 11:43
URI:	http://eprints.iisc.ac.in/id/eprint/85056

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