A neural network model for kindling of focal epilepsy: basic mechanism

Mehta, Mayank R and Dasgupta, Chandan and Ullal, Gautam R (1993) A neural network model for kindling of focal epilepsy: basic mechanism. In: Biological Cybernetics, 68 (4). pp. 335-340.

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Abstract

A simple neural network model is proposed for kindling-the phenomenon of generating epilepsy by means of repeated electrical stimulation. The model satisfies Dale's hypothesis, incorporates a Hebb-like learning rule and has low periodic activity in absence of shocks. Many of the experimental observations are reproduced and some new experiments are suggested. It is proposed that the main reason for kindling is the formation of a large number of excitatory synaptic connections due to learning.

Item Type:	Journal Article
Publication:	Biological Cybernetics
Publisher:	Springer
Additional Information:	The copyright of this article belongs to Springer.
Department/Centre:	Division of Physical & Mathematical Sciences > Physics
Date Deposited:	04 Dec 2006
Last Modified:	19 Sep 2010 04:31
URI:	http://eprints.iisc.ac.in/id/eprint/8475

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