Adaptable Biomolecule-Interactive Dual Colorimetric Chemosensor for Cu2+ and Pd2+: Insight from Crystal Structure, Photophysical Investigations, Real-Time Sampling, and Molecular Logic Circuits

Mandal, S and Das, A and Biswas, A and Halder, A and Mondal, D and Mondal, TK (2024) Adaptable Biomolecule-Interactive Dual Colorimetric Chemosensor for Cu2+ and Pd2+: Insight from Crystal Structure, Photophysical Investigations, Real-Time Sampling, and Molecular Logic Circuits. In: Crystal Growth and Design, 24 (3). pp. 1051-1067.

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Abstract

Considering the crisis of single probes for the simultaneous colorimetric detection of both Cu2+ and Pd2+ metal ions, which are toxic to living organisms even in trace amounts, in this communication, we report the facile synthesis and characterization, including single-crystal X-ray diffraction (SCXRD), of a single molecular probe (E)-3-((2-(methylthio)phenyl)diazenyl)-1,1�-biphenyl-4-ol (TABH). TABH is bioactive and avidly interacts with biomolecules such as BSA protein and CT DNA, as evidenced by spectrofluorometric and photometric tests. The probe is also proficient in the selective and swift colorimetric sensing of Cu2+ and Pd2+ ions in ACN/H2O (4/1 v/v, pH = 7.2) medium over other metal ions. The sensor�s ability to selectively bind the analytes is demonstrated by a noticeable color shift from yellow to reddish brown for Cu2+ and violet for Pd2+, which is clearly visible to the human eye. A detailed investigation of the recognition mechanism using Job�s plot, 1H nuclear magnetic resonance (NMR), infrared (IR) analysis, electrospray ionization (ESI) mass analysis, and density functional theory (DFT) calculations confirmed a 1:1 binding stoichiometry for both ions. Furthermore, the chemosensor exhibits a strong association affinity (7.61 � 104 and 1.42 � 105 M-1 for Cu2+ and Pd2+, respectively) and a low detection limit (54.8 and 5.32 nM for Cu2+ and Pd2+, respectively). Binding data and absorption studies revealed that Pd2+ had a higher affinity for the probe than Cu2+. This makes it simple for Pd2+ to replace Cu2+ in the TAB-Cu2+ complex, increasing Pd2+�s differential selectivity over Cu2+. Cu2+ sensing is reversible with the addition of both ethylenediaminetetraacetic acid (EDTA) and triphenylphosphine (PPh3), whereas Pd2+ sensing is exclusively reversible with the presence of PPh3 only. The sensing activities were also investigated with molecular logic operations of AND, OR, and NOT gates. In addition, the chemoprobe proved to be effective in identifying Cu2+ and Pd2+ in actual water samples. It was then converted into test strips, creating a portable device for on-site analysis and testing. © 2024 American Chemical Society

Item Type:	Journal Article
Publication:	Crystal Growth and Design
Publisher:	American Chemical Society
Additional Information:	The copyright for this article belongs to the American Chemical Society.
Keywords:	Biomolecules; Color; Colorimetry; Computer circuits; Crystal structure; Density functional theory; Electrospray ionization; Ligands; Metal complexes; Metal ions; Nuclear magnetic resonance; Probes; Single crystals; Timing circuits; Trace elements, Colorimetric chemosensor; Colorimetric detection; Crystals structures; Living organisms; Metals ions; Molecular logic; Photophysical investigation; Real-time sampling; Single probe; Trace amounts, Copper compounds
Department/Centre:	Division of Chemical Sciences > Solid State & Structural Chemistry Unit
Date Deposited:	09 Apr 2024 10:41
Last Modified:	09 Apr 2024 10:41
URI:	https://eprints.iisc.ac.in/id/eprint/84691

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