Effect of aspect ratio on the x-ray attenuation of nanoparticles: A theoretical study

Haghighi, RR and Chatterjee, S and Zarei, F and Jafari, A and Vani, VC and Pishdad, P and Moshiri, S and Akondi, V (2024) Effect of aspect ratio on the x-ray attenuation of nanoparticles: A theoretical study. In: Radiation Physics and Chemistry, 218 .

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Abstract

Purpose: There has been a significant focus on the potential applications of nanoparticle suspensions in the past few decades particularly as targeted contrast agents for specific pathological conditions. However, the question of optimal size and shape of nanoparticles for contrast enhancement is inadequately addressed. Methods: We present a comprehensive and conclusive theoretical analysis using first principles by considering the attenuating property of a single nanoparticle of any arbitrary shape. As a special case, ellipsoidal nanoparticles and nanorods are considered, for two independent directions of incidence of x-rays. These results are extended for a suspension of nanoparticles in a liquid. Results: It is seen that for a nanoparticle with dimensions much less than 1/μ(E), where μ(E) is the attenuation coefficient of the material, the attenuation by the nanoparticle is independent of its shape and size; and attenuation per unit mass reduces as the nanoparticle size increases. Conclusions: To achieve maximum attenuation, the nanoparticle sizes should be as small as possible, immaterial of the shape, as long as the dimensions are smaller than 150 nm. © 2024 Elsevier Ltd

Item Type:	Journal Article
Publication:	Radiation Physics and Chemistry
Publisher:	Elsevier Ltd
Additional Information:	The copyright for this article belongs to the Elsevier Ltd.
Keywords:	Aspect ratio; Computerized tomography; Nanorods, Aspect-ratio; Computed tomography; Contrast agent; Nanoparticle sizes; Nanoparticles suspension; Pathological conditions; Targeted contrast agents; Theoretical study; X-ray attenuation; X-ray attenuation coefficient, Nanoparticles, gold nanoparticle; iodine; nanoparticle; nanorod, Article; attenuation; incidence; particle size; theoretical study; x-ray computed tomography
Department/Centre:	Division of Physical & Mathematical Sciences > Instrumentation Appiled Physics
Date Deposited:	23 Apr 2024 10:22
Last Modified:	23 Apr 2024 10:22
URI:	https://eprints.iisc.ac.in/id/eprint/84615

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