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Crystal Structure, Quantum Chemical, Hirshfeld Surface and Molecular Docking of Organic Molecular Salt: 2-Amino-5-Chloropyridinium-2,4-Dihydroxybenzoate

Ponnusamy, K and Madhu, R and Athianna, M (2023) Crystal Structure, Quantum Chemical, Hirshfeld Surface and Molecular Docking of Organic Molecular Salt: 2-Amino-5-Chloropyridinium-2,4-Dihydroxybenzoate. In: Crystal Research and Technology .

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Official URL: https://doi.org/10.1002/crat.202300169


An organic molecular salt, 2-amino-5-chloropyridinium-2,4-dihydroxybenzoate (ACP-DHB) is synthesized by the slurry method followed by crystallization from methanol. The formation of molecular salt is initially confirmed by 1H and 13C nuclear magnetic resonance (NMR) spectral data. Single crystal X-ray diffraction (XRD) analysis shows that the crystal belongs to the monoclinic crystal system with space group, P21/n. Further, the supramolecular assembly involved the extensive network of N+�H···O� and N�H···O hydrogen bonds as well as C-Cl···O halogen bond. Using UV-Visible spectral data, the optical band gap is calculated and found to be 4.21 eV. Photoluminescence studies indicate the crystal has blue light emission properties. TG/DTA analysis shows that ACP-DHB is thermally stable up to 162 °C. The quantum chemical calculations and natural bond analysis (NBO) are performed at B3LYP/6-311G++ (d,p) basis set using Gaussian 09 software. The relative contributions of various intermolecular connections are discussed using Hirshfeld surface analysis and fingerprint plot illustration. The antibacterial and antifungal activity exhibits better inhibitory capacity against pathogens. Molecular docking revealed that ACP-DHB efficiently binds with the 1UAG and 5KEE targets and has strong binding ability to the proteins. ADMET factors and Lipinski's rule of five are used to predict drug likeness property. © 2023 Wiley-VCH GmbH.

Item Type: Journal Article
Publication: Crystal Research and Technology
Publisher: John Wiley and Sons Inc
Additional Information: The copyright for this article belongs to John Wiley and Sons Inc
Keywords: Crystal structure; Energy gap; Hydrogen bonds; Molecular modeling; Nuclear magnetic resonance; Quantum chemistry; Surface analysis; X ray diffraction analysis, Biological studies; Dihydroxybenzoate; Hirshfeld surfaces; Homo-lumo; Molecular docking; Molecular salts; Organics; Single crystal X-ray diffraction; Spectral data; X- ray diffractions, Single crystals
Department/Centre: Division of Chemical Sciences > Solid State & Structural Chemistry Unit
Date Deposited: 04 Mar 2024 09:44
Last Modified: 04 Mar 2024 09:44
URI: https://eprints.iisc.ac.in/id/eprint/84389

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