Deore, JP and De, M (2023) Synthesis of biologically important tetrahydroisoquinoline (THIQ) motifs using quantum dot photocatalyst and evaluation of their anti-bacterial activity. In: Organic and Biomolecular Chemistry, 21 (45). pp. 9049-9053.
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Abstract
Our study introduces an efficient photocatalytic approach for synthesizing biologically significant C1-substituted tetrahydroisoquinoline (THIQ) motifs, employing WS2 quantum dots (QDs) as catalysts. This method enables the formation of C-C and C-P bonds at the C1 position of the THIQ motif. The resulting compounds exhibit substantial antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA) bacteria, with low minimum inhibitory concentration (MIC) values. Notably, the WS2 QD catalyst demonstrates recyclability and suitability for gram-scale reactions, underscoring the sustainability and scalability of our approach. Overall, our research presents a versatile and cost-effective strategy for synthesizing C1-substituted THIQ derivatives, highlighting their potential as novel therapeutic agents in biology and medicinal chemistry. © 2023 The Royal Society of Chemistry.
| Item Type: | Journal Article |
|---|---|
| Publication: | Organic and Biomolecular Chemistry |
| Publisher: | Royal Society of Chemistry |
| Additional Information: | The copyright for this article belongs to the Authors. |
| Department/Centre: | Division of Chemical Sciences > Organic Chemistry |
| Date Deposited: | 06 Mar 2024 05:53 |
| Last Modified: | 06 Mar 2024 05:53 |
| URI: | https://eprints.iisc.ac.in/id/eprint/84346 |
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