Sarkar, D and Barik, S and Shee, S and Gonnade, RG and Biju, AT (2023) NHC-Catalyzed Enantioselective Synthesis of Tetracyclic δ-Lactones by (4 + 2) Annulation of ortho-Quinodimethanes with Activated Ketones. In: Organic Letters .
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Abstract
The N-heterocyclic carbene (NHC)-catalyzed generation of ortho-quinodimethanes (o-QDMs) from 9H-fluorene-1-carbaldehydes followed by the interception with activated ketones resulting in the enantioselective synthesis of tetracyclic δ-lactones is presented. High diastereoselectivity of products, remote C(sp3)-H functionalization, broad substrate scope, and mild reaction conditions are the notable features of the present (4 + 2) annulation. © 2023 American Chemical Society.
| Item Type: | Journal Article |
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| Publication: | Organic Letters |
| Publisher: | American Chemical Society |
| Additional Information: | The copyright for this article belongs to Authors. |
| Department/Centre: | Division of Chemical Sciences > Organic Chemistry |
| Date Deposited: | 18 Mar 2024 05:24 |
| Last Modified: | 18 Mar 2024 05:24 |
| URI: | https://eprints.iisc.ac.in/id/eprint/84327 |
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